Effect of  Phyllanthus amarus  on duck hepatitis B virus replication in vivo | Zendy

Niu Jianzhang | Zendy; Wang Yanyan | Zendy; Qiao Ming | Zendy; Gowans Eric | Zendy; Edwards Patrick | Zendy; Thyagarajan S. P. | Zendy; Gust Ian | Zendy; Locarnini Stephen | Zendy

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Effect of Phyllanthus amarus on duck hepatitis B virus replication in vivo

Author(s) -

Niu Jianzhang,

Wang Yanyan,

Qiao Ming,

Gowans Eric,

Edwards Patrick,

Thyagarajan S. P.,

Gust Ian,

Locarnini Stephen

Publication year - 1990

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890320404

Subject(s) - duck hepatitis b virus , virology , biology , viral replication , in vivo , phyllanthus , virus , hepatitis , hepadnaviridae , viral disease , genetics , botany

Nine ducks congenitally infected with the duck hepatitis B virus (DHBV) were treated either orally (four ducks for 10 weeks) or intraperitoneally (five ducks for 12 weeks) with the Indian traditional herbal remedy Phyllanthus amarus . Compared to placebo‐treated control ducks, these treatments did not result in a reduction of circulating viral DNA in the serum or in the level of viral DNA replication in the liver. In two of the five intraperitoneal‐treated ducks, a reduction in the levels of duck hepatitis B surface antigenaemia (DHBsAg) was observed. The data strongly suggest that Phyllanthus amarus has no significant inhibitory effect on DHBV DNA replication and only a minor effect on DHBsAg production.

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