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Effect of Phyllanthus amarus on duck hepatitis B virus replication in vivo
Author(s) -
Niu Jianzhang,
Wang Yanyan,
Qiao Ming,
Gowans Eric,
Edwards Patrick,
Thyagarajan S. P.,
Gust Ian,
Locarnini Stephen
Publication year - 1990
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890320404
Subject(s) - duck hepatitis b virus , virology , biology , viral replication , in vivo , phyllanthus , virus , hepatitis , hepadnaviridae , viral disease , genetics , botany
Abstract Nine ducks congenitally infected with the duck hepatitis B virus (DHBV) were treated either orally (four ducks for 10 weeks) or intraperitoneally (five ducks for 12 weeks) with the Indian traditional herbal remedy Phyllanthus amarus . Compared to placebo‐treated control ducks, these treatments did not result in a reduction of circulating viral DNA in the serum or in the level of viral DNA replication in the liver. In two of the five intraperitoneal‐treated ducks, a reduction in the levels of duck hepatitis B surface antigenaemia (DHBsAg) was observed. The data strongly suggest that Phyllanthus amarus has no significant inhibitory effect on DHBV DNA replication and only a minor effect on DHBsAg production.