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Detection of human herpesvirus 6 DNA in throat swabs by polymerase chain reaction
Author(s) -
Kido Shinji,
Kondo Kazuhiro,
Kondo Toshio,
Morishima Tsuneo,
Takahashi Michiaki,
Yamanishi Koichi
Publication year - 1990
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890320302
Subject(s) - virology , polymerase chain reaction , throat , dna , real time polymerase chain reaction , polymerase , biology , gene , genetics , anatomy
The detection of human herpesvirus 6 (HHV‐6) DNA was carried out in throat swabs of adults and children by the polymerase chain reaction, and isolation of virus was also attempted from peripheral mononuclear cells. Although virus was isolated only from peripheral blood mononuclear cells of infants with exanthem subitum, HHV‐6 DNA was detected in one of 30 healthy adults (3%), two of nine adults (22%) with common cold, two of 10 infants (20%) with exanthem subitum, four of 39 febrile children (10%) with antibody to HHV‐6 (including three of 10 infants aged under 1 year old, and one of 29 children aged over 1 year old). However, HHV‐6 DNA was not detected in samples from healthy neonates.