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Antigenic relatedness among the Norwalk‐like agents by serum antibody rises
Author(s) -
Madore H. Paul,
Treanor J. J.,
Buja R.,
Dolin R.
Publication year - 1990
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890320206
Subject(s) - norwalk virus , virology , titer , antigen , heterologous , antibody , biology , immunoassay , microbiology and biotechnology , virus , immunology , norovirus , biochemistry , gene
The Norwalk, Snow Mountain (SMA), and Hawaii agents are etiologically associated with separate outbreaks of acute viral gastroenteritis. Previous cross‐challenge of volunteers, immune electron microscopy, and/or enzyme‐immunoassay analysis suggested that these agents are antigenically distinct. We examined paired sera from human volunteers challenged with these agents for the presence of homologous and heterologous serum antibody titer rises to the agents. Two‐way cross‐reactions occurred between Hawaii agent and SMA. A one‐way cross‐reaction occurred between Norwalk agent and SMA, as volunteers challenged with Norwalk agent had heterologous serum antibody titer rises to SMA, but the reverse did not occur. The Norwalk and Hawaii agents had minimal cross‐reaction, with only one volunteer challenged with Hawaii agent having a heterologous rise to Norwalk agent. These observations indicate varying degrees of antigenic relatedness among these agents.