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Incidence of antibodies to human papillomavirus type 1 in patients with cutaneous and mucosal papillomas
Author(s) -
Viac Jacqueline,
Chomel JeanJacques,
Chardonnet Yvette,
Aymard Michèle
Publication year - 1990
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890320104
Subject(s) - papilloma , titer , antibody , medicine , incidence (geometry) , papillomaviridae , immunofluorescence , hpv infection , genital warts , antibody titer , virology , verruca vulgaris , indirect immunofluorescence , human papillomavirus , immunology , pathology , cancer , cervical cancer , physics , syphilis , human immunodeficiency virus (hiv) , optics
A study of antibodies to human papillomavirus (HPV) 1 is reported in a series of sera from 126 patients with papilloma lesions of different clinical types (verruca plantaris, vulgaris, plana, condyloma acuminata, laryngeal papilloma) using a sensitive solid‐phase enzyme‐linked immunosorbent assay (ELISA). Our findings showed a significant prevalence of specific HPV 1 IgG antibodies in patients with plantar warts (65%). This incidence was considerably lower in patients with other papilloma lesions, in which positive sera may reflect a past infection with HPV 1. The ELISA test was evaluated as nearly 100 times more sensitive than the indirect immunofluorescence test, and lgG titers to HPV 1 in patients' sera were usually low. Serum samples taken at different times during the course of HPV infection in a few patients with refractory lesions did not show any significant change in their antibody titer.