Premium
HIV excretion patterns and specific antibody responses in body fluids
Author(s) -
O'Shea Siobhan,
Cordery Mark,
Barrett Winsome Y.,
Richman Douglas D.,
Bradbeer Caroline,
Banatvala Jangu E.
Publication year - 1990
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890310409
Subject(s) - saliva , virology , antibody , semen , virus , biology , immunology , antigen , body fluid , viral load , nucleic acid , hiv antigens , viral disease , medicine , biochemistry , genetics
HIV excretion patterns and specific antibody responses were evaluated in blood, semen, female genital secretions, saliva, and crevicular fluid. Samples were examined for infectious virus, viral antigens, viral nucleic acid, HIV specific IgG, IgA, anti‐nef, and anti‐p24. Viral load in peripheral blood appeared to increase with disease progression. The proportion of patients with antibody responses specific for nef and p24 was also lower among patients with more advanced disease. Infectious virus and viral antigens were detected infrequently and at lower levels in body fluids than in blood, which may reflect the presence of local antibodies. HIV nucleic acid was detected in some semen and saliva samples in the absence of infectious virus.