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Anti‐PreS2 antibody assay for evaluating immune responses among recipients of recombinant hepatitis B PreS2+S vaccine
Author(s) -
Hurni William M.,
Roehm Robert R.,
Miller William J.
Publication year - 1990
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890300213
Subject(s) - virology , recombinant dna , antibody , immune system , immunogenicity , biology , immunology , gene , genetics
A competitive radioimmunoassay was developed for measuring hepatitis B virus (HBV) anti‐PreS2 antibody. The assay has been demonstrated to be highly specific for anti‐PreS2 antibody and not subject to interference by other antibodies to HBV‐specific antigens. This assay was used to evaluate anti‐PreS2 antibody responses in a hepatitis B PreS2+S vaccine human clinical trial in healthy adults.