The absence of hepatitis B virus DNA in hepatitis B e antigen positive sera from chronic hepatitis B surface antigen carriers in China | Zendy

Scott Janet S. | Zendy; Pan PeiEn | Zendy; Pace Raymond A. | Zendy; Sloots Theo P. | Zendy; Cooksley W. Graham | Zendy

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The absence of hepatitis B virus DNA in hepatitis B e antigen positive sera from chronic hepatitis B surface antigen carriers in China

Author(s) -

Scott Janet S.,

Pan PeiEn,

Pace Raymond A.,

Sloots Theo P.,

Cooksley W. Graham

Publication year - 1990

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890300205

Subject(s) - virology , hepatitis b virus , hepatitis b virus dna polymerase , hepatitis b , antigen , hepatitis , hepadnaviridae , virus , medicine , immunology , biology

Sera from 20 Chinese patients with chronic hepatitis B were examined for hepatitis B e antigen and hepatitis B virus (HBV) DNA. There was considerable discordance with HBV DNA not being detectable in 10 out of 13 (77%) patients who were hepatitis B e antigen positive. Further testing for anti‐HBe and HBV‐DNA polymerase activity confirmed the results. Possible reasons for this discordance are discussed but neither hepatitis D (delta) infection nor the acquired immunodeficiency syndrome (AIDS) could be implicated.

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