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Laboratory diagnosis of japanese encephalitis using monoclonal antibodies and correlation of findings with the outcome
Author(s) -
Ravi V.,
Vanajakshi S.,
Gowda Anke,
Chandramuki A.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890290313
Subject(s) - monoclonal antibody , virology , japanese encephalitis , encephalitis , antibody , medicine , biology , virus , immunology
Detection of virus, viral antigen, and class‐specific antibody was carried out in cerebrospinal fluid (CSF) and sera of 27 children with Japanese encephalitis. The diagnosis could be confirmed in 78.57% of cases (22/27) by demonstration of virus‐specific IgM in CSF (15/22), viral antigen in CSF (5/22), or by virus isolation (2/22). Absence of virus specific IgM in CSF was associated with a fatal outcome ( P = 0.05).