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Complement‐Independent neutralising monoclonal antibody with differential reactivity for strains of human cytomegalovirus
Author(s) -
Baboonian C.,
Blake K.,
Booth J. C.,
Wiblin C. N.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890290212
Subject(s) - virology , cytomegalovirus , monoclonal antibody , human cytomegalovirus , biology , glycoprotein , neutralization , herpesviridae , epitope , antibody , complement (music) , monoclonal , betaherpesvirinae , virus , microbiology and biotechnology , immunology , viral disease , gene , genetics , phenotype , complementation
A mouse monoclonal antibody with complement‐independent neutralising activity against cytomegalovirus (CMV) and reactive with the 86 kilodalton (kDa) viral glycoprotein H is described. Neutralisation tests against a range of different strains of CMV showed significant crossreactivity, but clear differences were evident between the two prototype viruses AD169 and Davis, and particularly between AD169 and several low‐passage recent clinical isolates; CMV present in urine was neutralised weakly if at all.