Premium
Tropism and histopathology of the d, b, k, and mm variants of encephalomyocarditis virus
Author(s) -
Cerutis Delie R.,
Bruner Richard H.,
Thomas Donald C.,
Giron David J.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890290112
Subject(s) - tropism , histopathology , virology , virus , tissue tropism , biology , pancreas , titer , disease , pathology , medicine , biochemistry
Variants of encephalomyocarditis virus (EMCV), which are immunologically indistinguishable by hyperimmune serum, produce different disease syndromes in mice. For instance, in ICR Swiss male mice, EMCV‐B produces no overt illness, EMCV‐MM produces severe neurological signs followed by death, EMCV‐D destroys pancreatic beta cells producing a disease syndrome resembling insulin‐dependent diabetes mellitus, and EMCV‐K is lethal but produces no overt signs of infection. The present study was done to determine the tissue tropism and histopathology of each of these EMCV variants in the ICR Swiss mouse model. The data show the highest concentrations in the following organs: EMCV‐D in the pancreas, EMCV‐B in the pancreas, EMCV‐MM in the cerebrum, and EMCV‐K in the medulla/brainstem. They also show that the pathological lesions produced by each variant correlate well with viral titers.