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Predilection of a nasopharyngeal carcinoma‐derived isolate of epstein‐barr virus for infection of specific subsets of B lymphocytes
Author(s) -
Tarr Kathleen L.,
Glaser Ronald
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890290109
Subject(s) - nasopharyngeal carcinoma , epstein–barr virus , virology , virus , biology , lymphoblast , antibody , gammaherpesvirinae , herpesviridae , immunology , cell culture , viral disease , medicine , genetics , radiation therapy
It is important to know whether there are variants of Epstein‐Barr virus (EBV) with biological properties that are different from the prototype viruses that have been studied in detail, such as P3HR‐1 and B95‐8. We have studied an EBV isolate derived from a nasopharyngeal carcinoma (NPC) tumor, designated NPC‐EBV. We have examined the target B lymphocytes infected and growth‐transformed with NPC‐EBV as compared with two common EBV isolates, B95‐8 and AG876 EBV, for stage of maturation using antibodies to several immunoglobulin chains. Typing of the NPC‐EBV transformed lymphoblastoid cell lines revealed the predilection of the NPC‐EBV isolate to infect immature B lymphocytes. This was not the case for the B95‐8 and AG876 isolates. The reason for the predilection of NPC‐EBV for immature B lymphocytes remains to be explored further. However, these results may be important in understanding the pathophysiology of EBV‐associated diseases.