Premium
Detection of hepatitis a virus rna in serum from patients with acute hepatitis
Author(s) -
Oren R.,
Shouval D.,
TurKaspa R.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890280411
Subject(s) - virology , hepatitis a virus , rna , virus , titer , hepatitis a , acute hepatitis , complementary dna , hepatitis , hepatitis c virus , medicine , biology , gene , biochemistry
Hepatitis A virus (HAV) RNA was extracted from the sera of patients with acute hepatitis and then detected by molecular hybridization using cloned HAV complementary DNA (cDNA). HAV RNA was detected in 20 of 85 patients with acute HAV infection, mainly during the prodromal stage, or early during the icteric phase of the disease; it was detected as long as 21 days after its initial detection. Patients with HAV RNA in the serum had a significantly higher titer of anti‐HAV IgM.