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Immune response of patients with congenital coagulation disorders to hepatitis b vaccine: Suboptimal response and human immunodeficiency virus infection
Author(s) -
Miller Elizabeth J.,
Lee Christine A.,
Holmes Sue,
Kernoff P. B. A.,
Thomas H. C.,
Karayiannis P.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890280208
Subject(s) - medicine , vaccination , immune system , immunology , virology , hepatitis b , hepatitis b vaccine , hepatitis b virus , virus , hbsag
Seventy‐eight patients with congenital coagulation disorders were treated with hepatitis B vaccine either subcutaneously or intradermally. All the children (eight vaccinated subcutaneously and eight vaccinated intradermally) responded. Seventeen of 19 (90%) anti‐HIV‐negative adults vaccinated subcutaneously and 14/25 (56%) anti‐HIV‐negative adults vaccinated intradermally showed an immune response. At 24 months, the anti‐HBs level was > 10 IU/I in all children vaccinated subcutaneously, 83% of children vaccinated intradermally, 77% of adults vaccinated subcutaneously, and 55% of adults vaccinated intradermally. Eight of 15 (53%) adult patients who were anti‐HIV positive were also anti‐HBc positive before vaccination and 6/8 (75%) failed to produce an amnestic response to vaccine. Subcutaneous vaccination with regular monitoring of anti‐HBs levels and appropriate boosting is recommended.