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Heterophile igm, iga, and ige antibodies in infectious mononucleosis
Author(s) -
Duverlie G.,
Driencourt M.,
Roussel C.,
Orfila J.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890280109
Subject(s) - mononucleosis , heterophile , virology , immunoglobulin e , antibody , immunology , immunoglobulin m , medicine , immunoglobulin g , virus
Fifty infectious mononucleosis (IM) and 150 noninfectious mononucleosis (non‐IM) sera were tested by a hemadsorption immunocapture test (HIT) for the detection of heterophile antibodies of IgM, IgA, and IgE classes. The specificity of Paul‐Bunnell (PB) antibodies was ascertained by a differential absorption test. IgM PB‐antibodies were demonstrated in 100% of IM sera, IgA in 92%, and IgE in 88%. PB antibodies were present only in IM sera; but other heterophile antibodies of IgM (68%), IgA (6.7%), and IgE (9.3%) classes were demonstrated in non‐IM sera. IgA and IgE heterophile antibodies were thus present, especially in IM sera. HIT was found to be more sensitive than Paul‐Bunnell Davidsohn test (PBD test) and suitable for the diagnosis of infectious mononucleosis.