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Effect of l‐lysine monohydrochloride on cutaneous herpes simplex virus in the guinea pig
Author(s) -
Ayala E.,
Krikorian D.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890280105
Subject(s) - herpes simplex virus , lysine , hsl and hsv , tropism , guinea pig , virology , inoculation , virus , medicine , amino acid , herpesviridae , biology , immunology , viral disease , biochemistry
The effect of topical applications of crystalline lysine therapy on cutaneous herpes simplex virus (HSV) inoculations and subsequent dorsal root ganglia (DRG) infection was studied in male Hartley guinea pigs. Although HSV‐I was recovered from the inoculated sites from all animals, the L‐lysine‐treated skin remained clinically normal, whereas untreated controls manifested clinical symptoms up to 3 days postinoculation (p.i.). However, cocultivation of DRG (C1‐S1) indicated a selective tropism of infective particles to specific DRG in the groups treated with amino acids. In lysine‐treated animals, HSV was recovered from a few DRG (T‐12, T‐13, and L‐1) at 3 days p.i. and from DRG T‐10 in leucine‐treated controls; yet no HSV was recovered from DRG of untreated controls. These results suggest an immunomodulatory effect of L‐lysine on inoculation site infections and the possible potentiation of subsequent DRG manifestation in amino‐acidtreated animals.