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Protective effect of a synthetic peptide comprising the complete pres2 region of the hepatitis b virus surface protein
Author(s) -
Emini Emilio A.,
Larson Vivian,
Ellis Ronald W.,
Miller William J.,
Gerety Robert J.,
Conard Patricia,
Garsky Victor M.,
Anderson Charles A.,
Eichberg Jorg,
Rick Lee D.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890280103
Subject(s) - virology , peptide , antigen , antibody , virus , biology , peptide sequence , epitope , hepatitis b virus , residue (chemistry) , microbiology and biotechnology , biochemistry , gene , immunology
Abstract A peptide was synthesized containing the entire 55 amino acid residue sequence of the hepatitis B virus (HBV) surface antigen preS2 region ( ad subtype). The unconjugated peptide was inoculated into four chimpanzees. Following multiple injections, all of the animals developed specific antipeptide antibodies that reacted with intact surface antigen particles bearing the preS2 moiety. All four peptide‐inoculated animals were found to be protected from infection after intravenous challenge with live HBV of either the ad or ay subtypes.