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Serum IgA antibodies in HSV asymptomatic genital infections
Author(s) -
Guglielmino S. P. P.,
Garozzo A.,
Pinizzotto M. R.,
Furneri P. M.,
Corbino N.,
Castro A.,
Cianci S.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890270306
Subject(s) - virology , asymptomatic , antibody , hsl and hsv , immunology , genital herpes , sex organ , medicine , biology , virus , herpes simplex virus , pathology , genetics
Cervico‐vaginal swabs and serum samples from 81 women without herpes‐associated clinical symptoms were examined for virus isolation and for the presence of IgA antibodies to herpes simplex virus (HSV) using the indirect fluorescent antibody technique. Nineteen of the 81 women were followed up for 2 years. Blood samples and swabs from cutaneous lesions were obtained from another group of 20 women (medical staff) with herpes labialis. By analysing the specific anti‐HSV IgA antibodies, a higher geometric mean titre (GMT) was found in women with positive HSV‐2 isolation (GMT = 380.03), as opposed to the GMT observed in women with negative HSV‐2 (GMT = 63.43) or positive HSV‐1 isolation (GMT = 55.15). Results from the longitudinal study also demonstrated that positive virus isolation always correlated with a marked rise in serum IgA antibody to HSV.