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Lymphocyte subsets alteration in patients with argentine hemorrhagic fever
Author(s) -
Vallejos Daniel A.,
Ambrosio Ana M.,
Feuillade María R.,
Maiztegui Julio I.
Publication year - 1989
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890270218
Subject(s) - convalescence , monoclonal antibody , immunology , antibody , virology , medicine , lymphocyte , disease , peripheral blood mononuclear cell , biology , in vitro , biochemistry
Abstract Peripheral blood lymphocyte subpopulations were studied in 15 patients with Argentine Hemorrhagic Fever (AHF), during the acute period of the disease and in early convalescence. Antihuman lg antibodies were used to identify B cells and monoclonal antibodies to assess T4 and T8 subsets. During the acute period of the disease, significant alterations were found in B, T4, and T8 lymphocytes ( P < 0.001), as well as in T4/T8 ratios ( P < 0.001). These abnormalities disappeared in early convalescence, around 30 days after the clinical onset. Diminished numbers of T4 lymphocytes are interpreted as relevant to the immunodepression that characterizes the acute phase of AHF.