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Prevalence of genital HPV infections in a regularly screened population in the netherlands in relation to cervical cytology
Author(s) -
Melchers Willem J. G.,
Herbrink Paul,
Quint Wim G. V.,
Walboomers Jan M. M.,
Meijer Chris J. L. M.,
Lindeman Jan
Publication year - 1988
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890250103
Subject(s) - cytology , dysplasia , cervix , population , sex organ , medicine , cervical cancer , gynecology , carcinoma in situ , virology , hpv infection , genotype , liquid based cytology , carcinoma , pathology , biology , cancer , gene , genetics , environmental health
To determine the prevalence of human papilloma virus (HPV) genotypes in relation to cervical cytology, 1,290 cervical samples from a regularly screened population of 30‐55‐year‐old women were investigated. Gynaecological specimens, obtained from the cervix, were cytologically classified and screened for the presence of HPVs 6/11 and 16/18 using dot‐spot DNA hybridisation. Of the cervical samples containing unequivocally normal cells, 21 of 1,271 (1.6%) were found positive for HPV, and of the cervical samples containing cells with mild dysplasia, 6 of 14 (43%) were found positive for HPV. All five samples containing cells consistent with severe dysplasia or carcinoma in situ were found positive for HPV. Approximately 50% of the HPV positive samples contained HPV 16 and/or HPV 18 DNA.