Prevalence of genital HPV infections in a regularly screened population in the netherlands in relation to cervical cytology | Zendy

Melchers Willem J. G. | Zendy; Herbrink Paul | Zendy; Quint Wim G. V. | Zendy; Walboomers Jan M. M. | Zendy; Meijer Chris J. L. M. | Zendy; Lindeman Jan | Zendy

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Prevalence of genital HPV infections in a regularly screened population in the netherlands in relation to cervical cytology

Author(s) -

Melchers Willem J. G.,

Herbrink Paul,

Quint Wim G. V.,

Walboomers Jan M. M.,

Meijer Chris J. L. M.,

Lindeman Jan

Publication year - 1988

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890250103

Subject(s) - cytology , dysplasia , cervix , population , sex organ , medicine , cervical cancer , gynecology , carcinoma in situ , virology , hpv infection , genotype , liquid based cytology , carcinoma , pathology , biology , cancer , gene , genetics , environmental health

To determine the prevalence of human papilloma virus (HPV) genotypes in relation to cervical cytology, 1,290 cervical samples from a regularly screened population of 30‐55‐year‐old women were investigated. Gynaecological specimens, obtained from the cervix, were cytologically classified and screened for the presence of HPVs 6/11 and 16/18 using dot‐spot DNA hybridisation. Of the cervical samples containing unequivocally normal cells, 21 of 1,271 (1.6%) were found positive for HPV, and of the cervical samples containing cells with mild dysplasia, 6 of 14 (43%) were found positive for HPV. All five samples containing cells consistent with severe dysplasia or carcinoma in situ were found positive for HPV. Approximately 50% of the HPV positive samples contained HPV 16 and/or HPV 18 DNA.

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