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Significance of maternal and infant serum antibodies to hepatitis B core antigen in hepatitis B virus infection of infancy
Author(s) -
Panda S. K.,
Bhan M. K.,
Guha D. K.,
Gupta A.,
Datta R.,
Zuckerman A. J.,
Nayak N. C.
Publication year - 1988
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890240311
Subject(s) - transplacental , hepatitis b virus , virology , hbsag , medicine , antibody , hepatitis b , immunology , transmission (telecommunications) , antigen , immunoglobulin m , fetus , virus , pregnancy , immunoglobulin g , biology , placenta , genetics , electrical engineering , engineering
The significance of IgM and IgG class antibodies to hepatitis B virus (HBV) core component (anti‐HBc) was investigated in a study of maternal‐fetal HBV transmission. An IgM anti‐HBc response was lacking in the majority (49/53) of HBV‐infected infants. This antibody thus cannot be used as an indicator of transplacental infection. However, most infants who became HBsAg positive during the first 6 months of life acquire infection in the perinatal period rather than transplacentally. Passively transferred maternal IgG anti‐HBc in the infant and additional IgM anti‐HBc positively in the carrier mother have no modulating influence on HBV infection of infants born to HBV carrier women.