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Serologic characteristics of a human rotavirus isolate, AU‐1, which has a “long” RNA pattern and subgroup I specificity
Author(s) -
Kitaoka S.,
Nakagomi T.,
Fukuhara N.,
Hoshino Y.,
Suzuki H.,
Nakagomi O.,
Kapikian A. Z.,
Ebina T.,
Konno T.,
Ishida N.
Publication year - 1987
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890230407
Subject(s) - antiserum , virology , serotype , strain (injury) , titer , rotavirus , serology , biology , neutralization , hemagglutination , hemagglutination assay , reoviridae , gene , rna , virus , antibody , genetics , anatomy
An unusual human rotavirus (HRV) isolate, designated AU‐1, has a “long” RNA electrophoretic pattern and subgroup I specificity, in contrast to properties common to HRVs previously isolated. Hemagglutination activity of the AU‐1 strain was demonstrated using erythrocytes of 1‐day‐old chicken. Neutralization assays revealed that the AU‐1 strain was crossneutralized by hyperimmune antisera against the MO strain (serotype 3). However, antiserum directed against a reassortant in which the gene for Vp7 was replaced by the corresponding AU‐1 gene neutralized the AU‐1 strain to a significantly higher titer than the MO strain.