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Specific serum IgA in rotavirus gastroenteritis
Author(s) -
Angeretti A.,
Magi M. T.,
Merlino C.,
Ferrara B.,
Ponzi A. Negro
Publication year - 1987
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890230406
Subject(s) - rotavirus , virology , immunoglobulin a , acute gastroenteritis , immune system , virus , antibody , immunoglobulin m , rotavirus gastroenteritis , immunology , biology , immunoglobulin g , medicine
Virus‐specific serum IgM, IgA, and IgG were detected by ELISA in sera obtained from children with rotavirus gastroenteritis and fractionated by gel filtration. Specific IgM and IgG could be easily demonstrated, whereas IgA were very low. Moreover, polymeric IgA (p‐IgA) were not present, whereas in the immune response against viruses causing systemic infections, they are synthetised in large amounts.