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Therapeutic effect of (E)‐5‐(2‐bromovinyl)‐2′‐deoxyuridine, caffeic acid oxidation product, and trisodiumphosphonoformate on cutaneous herpes simplex virus type 1 infection in guinea pigs
Author(s) -
Helbig Bjorn,
Sauerbrei Andreas,
Klöcking Renate,
Wutzler Peter,
Wicht Norbert,
Wiedemann Uwe,
Herrmann Gottfried
Publication year - 1987
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890230314
Subject(s) - herpes simplex virus , virology , virus , caffeic acid , deoxyuridine , guinea pig , aciclovir , inoculation , chemistry , simplexvirus , idoxuridine , herpesviridae , pharmacology , medicine , viral disease , biochemistry , immunology , antioxidant , endocrinology , dna
The influence of (E)‐5‐(2‐bromovinyl)‐2′‐deoxyuridine (BVDU), caffeic acid oxidation product (KOP), and trisodiumphosphonoformate (TPF) on the course of the primary cutaneous herpes simplex virus infection was investigated by means of a guinea pig test model. The antiviral substances were applied in an ointment with 10% urea as a penetration mediator. When the treatment was initiated 15 minutes after virus inoculation, 3% BVDU effectively inhibited the development of herpetic vesicles and 0.1% BVDU prevented the appearance of herpetic satellites. Under the same conditions 1% and 3% KOP ointments inhibited the appearance of satellites; and 0.5% TPF ointment completely inhibited the development of cutaneous herpes lesions. Prophylactic drug administration given 24, 20, and 4 hours before virus inoculation was without any protective effect.