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Isolation of human immunodeficiency virus (HIV) from plasma during primary HIV infection
Author(s) -
Albert Jan,
Gaines Hans,
Sönnerborg Anders,
Nyström Gunnel,
Pehrson Pehr Olov,
Chiodi Francesca,
von Sydow Madeleine,
Moberg Lars,
Lidman Knut,
Christensson Bertil,
Åsjö Birgitta,
Fenyö Eva Maria
Publication year - 1987
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890230108
Subject(s) - virology , human immunodeficiency virus (hiv) , isolation (microbiology) , virus , viral disease , lentivirus , sida , virus isolation , biology , medicine , microbiology and biotechnology
Human immunodeficiency virus (HIV) has been isolated from plasma in 6 of 7 patients showing clinical symptoms of a primary HIV infection. Parallel cultures from peripheral blood mononuclear cells (PBMC) yielded virus in 5 patients. In one case, virus could only be isolated from the cerebrospinal fluid but not from peripheral blood. Detectable viremia was transient and preceded the appearance of HIV specific antibodies. After cessation of acute symptoms, the frequency of HIV isolations was similar to that of asymptomatic carriers (23 and 26%, respectively). The role of the immune response in terminating detectable viremia remains to be established.