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Anti‐Delta antibody in various HBsAg positive argentine populations
Author(s) -
Fay O.,
Tanno H.,
Gatti H.,
Basualdo J. A.,
Ciocca M.,
Fainboin H.,
Fainboin L.,
Jorge A.,
Motta A.,
Naval M.,
Palazzi J.,
Ramonet M.,
Rey J.,
Rojman J.,
Schujman L.,
Sileoni S.,
Terg R.,
Villamil F.
Publication year - 1987
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890220309
Subject(s) - hbsag , fulminant hepatitis , medicine , hepatitis d , hbeag , antibody , cirrhosis , hepatitis , virology , volunteer , immunology , hepatitis b , antigen , liver disease , gastroenterology , virus , hepatitis b virus , biology , agronomy
One thousand five hundred and seventeen HBsAg carriers from different cities of Argentina were studied for the presence of anti‐Delta antibody (anti‐HDV) in their sera. One thousand one hundred and sixty‐eight were volunteer blood donors and 349 were patients with liver disease. Different liver diseases were diagnosed by clinical, biochemical, and histological parameters. Among blood donors, 16 (1.4%) were positive for the antibody and none was Delta‐antigen positive. In 130 patients with acute hepatitis, one (0.77%) was positive for anti‐HDV. as well as three (2.22%) out of 135 patients with chronic active hepatitis (CAH), and three (5.77%) out of 52 patients with cirrhosis (C). No anti‐HDV positive was found among seven fulminant hepatitis (FH) cases. The presence of HBeAg and anti‐HBe was studied in anti‐HDV positive sera; eleven (69%) volunteer blood donors were anti‐HBe positive, and five (31%) were HBeAg positive. HBeAg was positive in the three CAH cakes, and in one out of three C Cases with anti‐HDV positive. Hepatitis Delta antigen was also positive in the hepatocytic nuclei in the three patients with C and two of the three CAH cases. The present results show that Delta infection is rare among blood donors in Argentina. A small variation without statistical significance could be found within different geographical areas. Among patients with HBsAg related liver disease, the presence of HDV markers was also low.