Cellular Immunity and T‐Lymphocyte Subsets in Young Children With Acute Measles | Zendy

Dagan Ron | Zendy; Phillip Moshe | Zendy; Sarov Israel | Zendy; Skibin Agneta | Zendy; Epstein Sarah | Zendy; Kuperman Oded | Zendy

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Cellular Immunity and T‐Lymphocyte Subsets in Young Children With Acute Measles

Author(s) -

Dagan Ron,

Phillip Moshe,

Sarov Israel,

Skibin Agneta,

Epstein Sarah,

Kuperman Oded

Publication year - 1987

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890220209

Subject(s) - measles , immunology , cytotoxic t cell , suppressor , lymphocyte , immunity , cellular immunity , t lymphocyte , medicine , measles virus , immune system , virology , biology , vaccination , in vitro , biochemistry , cancer

The changes occurring in the T‐cell subsets during acute symptomatic measles were examined in ten malnourished and 18 well nourished hospitalized children younger than 5 years of age (median age 14 months). A significant decrease in total lymphocyte count was observed. which was due mainly to a decrease in helper/inducer T lymphocytes, whereas the suppressor/cytotoxic T‐lymphocyte subset remained unchanged. Consequently, helpdsuppressor ratio decreased significantly during the acute phase of the disease. A reduced response to mitogens (PHA, Con A, PWM) was also observed. Malnourished infants showed a trend toward a deeper depression in both helper and suppressor T cells during the acute phase than well nourished children, whereas the helper/suppressor ratio remained similar in the two groups.

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