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Cellular Immunity and T‐Lymphocyte Subsets in Young Children With Acute Measles
Author(s) -
Dagan Ron,
Phillip Moshe,
Sarov Israel,
Skibin Agneta,
Epstein Sarah,
Kuperman Oded
Publication year - 1987
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890220209
Subject(s) - measles , immunology , cytotoxic t cell , suppressor , lymphocyte , immunity , cellular immunity , t lymphocyte , medicine , measles virus , immune system , virology , biology , vaccination , in vitro , biochemistry , cancer
The changes occurring in the T‐cell subsets during acute symptomatic measles were examined in ten malnourished and 18 well nourished hospitalized children younger than 5 years of age (median age 14 months). A significant decrease in total lymphocyte count was observed. which was due mainly to a decrease in helper/inducer T lymphocytes, whereas the suppressor/cytotoxic T‐lymphocyte subset remained unchanged. Consequently, helpdsuppressor ratio decreased significantly during the acute phase of the disease. A reduced response to mitogens (PHA, Con A, PWM) was also observed. Malnourished infants showed a trend toward a deeper depression in both helper and suppressor T cells during the acute phase than well nourished children, whereas the helper/suppressor ratio remained similar in the two groups.