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Treatment of cytomegalovirus pneumonitis with foscarnet (trisodium phosphonoformate) in patients with AIDS
Author(s) -
Farthing C.,
Anderson M. G.,
Ellis M. E.,
Gazzard B. G.,
Chanas A. C.
Publication year - 1987
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890220206
Subject(s) - foscarnet , medicine , pneumonitis , cytomegalovirus , bronchoalveolar lavage , virology , superinfection , gastroenterology , herpesviridae , lung , viral disease , virus
Foscarnet was administered to eight AIDS patients for suspected cytomegalovirus (CMV) pneumonitis as a continuous intravenous infusion for a minimum of 8 days. All the patients improved, three showing complete resolution of symptoms. Evidence of CMV infection from bronchoalveolar lavage samples was lacking in two patients. Adverse drug experiences consisted of thrombophlebitis. Transient decreases in haemoglobin concentration, and reversible rises in serum creatinine levels.