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Hepatitis delta (δ) cDNA clones: Undetectable hybridization to nucleic acids from infectious non‐A, non‐B hepatitis materials and hepatitis B DNA
Author(s) -
Weiner A. J.,
Wang K.S.,
Choo Q.L.,
Houghton M.,
Bradley D. W.,
Gerin J. L.
Publication year - 1987
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890210307
Subject(s) - virology , complementary dna , nucleic acid , biology , hepatitis b , nucleic acid thermodynamics , hepatitis , hepatitis b virus dna polymerase , hepatitis b virus , dna , rna , genome , titer , hepatitis b virus pre beta , virus , microbiology and biotechnology , gene , genetics
Hepatitis Delta(δ) cDNA clones were hybridized to RNA extracted from livers of chimpanzees infected with the blood‐borne Non‐A, Non‐B hepatitis (NANBH) agent(s) and to total nucleic acids extracted from chimpanzee plasma containing a high titer of these NANBH agent(s). Since no hybridization was observed, the data suggests that the hepatitis Delta viral genome is not closely related to the genome(s) of the NANB agent(s). Our studies, in which the Hepatitis B virus genomic DNA was hybridized to hepatitis Delta cDNA clones, also confirm and extend previous studies [Hoyer et al, 1983], which report a lack of detectable homology between the hepatitis Delta genome and HBV DNA.