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Unusual Monocyte‐Lymphocyte Interactions Determine the Specificity of the Immune‐specific Interferon Response Induced by Newcastle Disease and Herpes Simplex Viruses
Author(s) -
Green Jon A.
Publication year - 1986
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890200411
Subject(s) - immune system , interferon , virology , virus , monocyte , herpes simplex virus , biology , newcastle disease , lymphocyte , interferon gamma , peripheral blood mononuclear cell , immunology , in vitro , biochemistry
Abstract Virus‐induced immune‐specific interferon (IS‐IFN) is produced by previously sensitized peripheral blood mononuclear leukocytes (PBML) three to five days after they are placed in tissue culture. This IS‐IFN is readily identified on the basis of its time of production and its synergistic composition of alpha and gamma interferons. The current studies demonstrate that circulating monocytes control the specificity and magnitude of the IS‐IFN response. No IS‐IFN is produced by PBML that are heavily depleted of monocytes. Immune‐specific IFN production is enhanced in PBML cultures that are partially depleted of monocytes. Partial monocyte depletion permits virus to induce the production of IS‐IFN by unsensitized PBML.