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Thermostabilization of Inoue‐Melnick Virus by Salt
Author(s) -
Nishibe Yoko,
Inoue Yukishige K.,
Melnick Joseph L.
Publication year - 1986
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890200203
Subject(s) - distilled water , herpes simplex virus , chemistry , salt (chemistry) , virus , salt solution , virology , biology , chromatography
Abstract Inoue‐Melnick virus (IMV) was stabilized to thermal inactivation at 50°C by 1 M Na 2 S0 4 but not by 1 M MgC1 2 , 1 M MgS0 4 , 2 M NaC1, and 2 M KCl. The latter salts enhanced the inactivation over that in distilled water. Na2S04 stabilized IMV at 1 M concentration but enhanced inactivation at 0.1 M. Three types of IMV were stabilized by 1 M Na 2 S0 4 at 50°C to almost the same degree. The pattern of the thermostabilization of IMV by salts was similar to that of herpes simplex virus; however, the degree of its stabilization was lower with prolonged heating.