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Lack of Complement‐Dependent Cytolytic Antibodies in Hepatitis A Virus Infection
Author(s) -
Gabriel Peter,
Vallbracht Angelika,
Flehmig Bertram
Publication year - 1986
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890200105
Subject(s) - cytolysis , virology , antibody , herpes simplex virus , virus , biology , immunology , cytotoxicity , in vitro , biochemistry
Sera collected from patients with acute hepatitis A virus (HAV) infection and convalescent sera were examined for cytolytic activity against HAV‐infected human‐embryo lung fibroblasts (HAV carrier fibroblasts). Using the 51 chromium release assay, no complement dependent antibody mediated cytolytic activity against HAV carrier cells could be detected. In control experiments with identical cell strains, anti‐herpes simplex virus (HSV) positive sera and complement caused specific lysis of HSV type 1 infected target cells. The data presented here do not support the hypothesis that in the possible immunopathogenesis of HAV infection, complement‐dependent cytolytic antibodies play an essential role.