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Antibody response to the rubella virus structural proteins in infants with the congenital rubella syndrome
Author(s) -
de Matancourt Anne,
Waxham M. N.,
Nicolas J. C.,
Wolinsky Jerrr Y. S.
Publication year - 1986
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890190203
Subject(s) - rubella , rubella virus , virology , antibody , hemagglutination assay , titer , serology , immunoprecipitation , virus , glycoprotein , medicine , neutralizing antibody , antibody titer , biology , immunology , microbiology and biotechnology , vaccination , measles
Abstract Forty‐five serum samples from 31 newborns and infants with the congenital rubella syndrome (CRS) were tested by immunoprecipitation to determine their antibody spectra to each of the structural proteins of rubella virus. Most sera (37/45) contained little or no E2 protein‐specific antibody, but some (6/45) precipitated a greater amount of the E2 glycoprotein than the El glycoprotein. The relative E1/E2 ratio was found to decrease with time when serial serum samples from the same patient were tested. No correlation between the IgG class hemagglutination inhibition antibody titers and the E1/E2 ratio could be demonstrated. However, in some serum specimens relatively high neutralizing antibody titers were correlated with immunoprecipitation of the E2 glycopolypeptide. None of the CRS sera reacted well with the C protein. The immunoprecipitation patterns found in CRS sera were qualitatively different from those observed in a series of 25 sera from young adults with conventional serologic evidence of rubella immunity following natural infection. All of the natural immune sera recognized each of the three structural polypeptides of rubella virus.