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Establishment and characterization of a chronic infectious mononucleosislike syndrome in common marmosets
Author(s) -
Emini Emilio A.,
Luka Janos,
Armstrong Marcy E.,
Banker Franklyn S.,
Provost Philip J.,
Pearson Gary R.
Publication year - 1986
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890180410
Subject(s) - virology , biology , medicine
Epstein‐Barr virus (EBV) was inoculated into two species of marmosets. Successful infection was established in the majority of the animals of one species, Callithrix jacchus , as evidenced by the development of high, persistent levels of antibody against virus‐specific capsid and early nonstructural proteins. Antibodies also were produced against the major membrane antigen and, in some animals, against EBV nuclear antigen (EBNA) 2 but not against EBNA 1. This is the antibody profile normally noted in individuals with chronic infectious mononucleosis (IM). EBV‐induced lymphoproliferation was not seen, and EBV‐specific proteins were not detected in the peripheral blood lymphocytes of infected animals. Hence, EBV infection in C. jacchus apparently does not generally include extensive B‐cell involvement. However, the marmosets clearly are useful as a model for EBV primary infection and also possibly for chronic IM.