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Inhibitory effect of acyclovir on the growth of inoue‐melnick virus isolated from cerebrospinal fluid
Author(s) -
Nishibe Yoko,
Inoue Yukishige K.
Publication year - 1986
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890180403
Subject(s) - virology , cerebrospinal fluid , in vitro , virus , inhibitory postsynaptic potential , serotype , cytopathic effect , mutant , cell culture , biology , microbiology and biotechnology , chemistry , biochemistry , neuroscience , gene , genetics
Inoue‐Melnick virus (IMV) was isolated from the cerebrospinal fluid of patients with chronic neurologic disorders. The effect of acyclovir (ACV), 9‐(2‐hydroxyethoxymethyl)‐guanine, on the growth of IMV was studied in human diploid cell cultures. ACV markedly inhibited the multiplication of all three IMV serotypes in vitro with the same inhibitory effect. By passage of IMV in the presence of ACV in the medium, ACV‐resistant mutants of three IMV serotypes were easily isolated.