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Molecular epidemiology of rotavirus infections in Uppsala, Sweden, 1981: Disappearance of a predominant electropherotype
Author(s) -
Svensson Lennart,
Uhnoo Ingrid,
Grandien Monica,
Wadell Göran
Publication year - 1986
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890180202
Subject(s) - rotavirus , virology , reoviridae , serology , molecular epidemiology , virus , rna , epidemiology , acute gastroenteritis , biology , viral disease , medicine , genetics , antibody , genotype , gene , pathology
The molecular epidemiology of rotavirus infections was studied in children with acute gastroenteritis in Uppsala, Sweden, during 1981. Altogether 118 virus strains were investigated by analysis of the RNA migration pattern in silver‐stained polyacrylamide gels. Six different electropherotypes were seen: two with “short” and four with “long” RNA migration patterns. Forty‐two strains (36%) exhibited “short” patterns. The seasonal distribution showed that strains with “long” and “short” RNA patterns cocirculated in equal frequency during the first seven months of the year, until the predominant “short” RNA electropherotype suddenly disappeared. More than 11 RNA segments were seen in two stool specimens. A complete correlation was found between the electrophoretic migration of segments 10 and 11 and the serological defined subgroup specificity.