Premium
Acute glandular fever‐like illness in a patient with HTLV‐III antibody
Author(s) -
McCaul T. F.,
Tovey G.,
Farthing C. F.,
Gazzard B.,
Zuckerman A. J.
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890170211
Subject(s) - endoplasmic reticulum , pathology , cytoplasm , virology , reticular connective tissue , reticular cell , virus , lymph node , antibody , lymph node biopsy , pathological , biology , biopsy , medicine , immunology , microbiology and biotechnology , spleen
A lymph node biopsy obtained from a patient with human T‐cell lymphocytotropic virus III/lymphadenopathy‐associated virus (HTLV‐III/LAV) antibody, presenting with an acute glandular fever‐like illness, was examined by electron microscopy. Numerous pathological changes were present in the biopsy, including hypertrophy of smooth endoplasmic reticulum, intracytoplasmic rod‐like inclusions within the cisternae of endoplasmic reticulum, multivesicular bodies, test‐tube and ringshaped forms, and tubulo‐reticular structures. Intranuclear and intracytoplasmic viral‐like particles measuring 105‐ 120 nm in diameter and small cytoplasmic particles measuring 50–70 nm in diameter were found in some degenerating lymph node cells. These pathological findings may reflect a host cell response to various pathological and viral stimuli resulting from immune deficiency owing to infection with HTLV‐III/LAV.