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Antibody to Epstein‐Barr virus‐specific DNase as a marker for the early detection of nasopharyngeal carcinoma
Author(s) -
Chen JenYang,
Liu MeiYing,
Chen ChienJen,
Hsu MowMing,
Tu ShihMien,
Lee HongHsin,
Kuo ShiowLing,
Yang CzauSiung
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890170107
Subject(s) - nasopharyngeal carcinoma , antibody , virus , epstein–barr virus , virology , carcinoma , biology , immunology , medicine , pathology , radiation therapy
We have previously shown that high levels of antibody to Epstein‐Barr virus (EBV)‐specific DNase may be a useful marker for the early diagnosis of nasopharyngeal carcinoma (NPC). Sera from 3,368 males in an area with a high risk for the development of NPC were examined for the presence of antibody to EBV‐specific DNase activity. Significant levels of the antibody were found in 430 of these sera. As a result, 32 individuals have attended the out‐patient department of otolaryngology for clinical examination. Among them, one individual was found to have a stage II nasopharyngeal carcinoma. This result supports the value of determination of antibody to EBV‐specific DNase as a marker for the early detection of NPC.