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Immunespecific interferon production by peripheral blood mononuclear leukocytes from patients with primary and recurrent orolabial herpes simplex virus infections
Author(s) -
Green Jon A.,
Weiss Paul N.,
Yeh TzeJou,
Spruance Spotswood L.
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890160311
Subject(s) - herpes labialis , virology , herpes simplex virus , peripheral blood mononuclear cell , interferon , immunology , virus , medicine , viral disease , herpesviridae , biology , in vitro , biochemistry
Immunespecific IFN (IFN) is produced by the peripheral blood mononuclear leukocytes (PBML) of greater than 95% of HSV‐seropositive humans with infrequent recurrences of herpes labialis [Green, Yeh, and Overall, 1981]. However, herpes virus‐induced immunespecific IFN was produced by PBML from only 33 of 48 (68.8%) persons with frequent recurrences (2–12 episodes a year). Two of eight subjects with primary herpes gingivostomatitis also failed to produce immunespecific IFN during either the acute or convalescent phases of their initial HSV infection. These data suggest that some persons have a defective immunespecific IFN response that exists from the time of their primary orolabial HSV type 1 infection. This defect may predispose to a higher frequency of disease in some individuals.