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Immunostimulatory function of herpes simplex virus isolates from patients with frequent herpes labialis and a deficiency in immunespecific interferon production
Author(s) -
Klieman Rachel L.,
Green Jon A.,
Spruance Spotswood L.
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890160310
Subject(s) - herpes labialis , virology , herpes simplex virus , interferon , virus , titer , hsl and hsv , biology , herpesviridae , simplexvirus , viral disease , immunology , peripheral blood mononuclear cell , medicine , in vitro , biochemistry
Approximately 30% of persons with frequent episodes of herpes labialis are deficient in the production of HSV‐induced immunespecific interferon (IFN) (Green, 1985). Herpes simplex virus (HSV) strains isolated from persons who make immunespecific IFN and from persons who do not make it were examined for their immunostimulatory capabilities. HSV isolated from the primary oral lesions of two patients deficient in immunespecific IFN production, one person with an intact immunespecific IFN response, HSV types 1 and 2 laboratory strains, and Newcastle disease virus (NDV) were added to cultures of peripheral blood mononuclear cells (PBML) from HSV seropositive donors. All HSV‐isolates induced comparable titers of immunespecific IFN. These studies suggest that failure of some patients to develop an immunespecific IFN response is determined by the host, not the virus.