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Serum antibodies to the major HSV‐2‐ specified DNA‐binding protein in patients with an acute HSV infection or cervical neoplasia
Author(s) -
Lehtinen Matti,
Lehtinen Tuula,
Koivisto Vesa,
Paavonen Jorma,
Leinikki Pauli
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890160305
Subject(s) - antigenicity , hsl and hsv , antibody , virology , immunology , biology , virus , medicine
The major HSV‐2‐specified DNA‐binding protein (ICSP 11/12) was purified from HSV‐infected cells. ELISA and immunoblotting techniques were used to study its antigenicity in HSV‐infected patients and patients with cervical neoplasia and control women. Patients with an acute HSV‐2 infection had clearcut antibody responses to the purified ICSP 11/12 preparation. Determination of the ICSP 11/12 antibodies by ELISA revealed considerably higher serum antibody levels in patients with cervical carcinoma than in the controls.