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Kinetics of specific IgA, IgD, IgE, IgG, and IgM antibody responses in rubella
Author(s) -
Salonen EevaMarjatta,
Hovi Tapani,
Meurman Olli,
Vesikari Timo,
Vaheri Antti
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890160102
Subject(s) - immunoglobulin d , antibody , immunoglobulin e , immunology , rubella , rubella virus , immunoassay , immunoglobulin m , immunoglobulin g , virology , biology , medicine , measles , b cell , vaccination
Rubella‐specific IgD and IgE antibodies were determined with a solid‐phase enzyme immunoassay using enzyme‐labeled heavy‐chain specific anti‐immunoglobulins, and the antibody responses in rubella infection were compared to IgM, IgA, and IgG antibodies. IgD and IgE antibodies increased rapidly after the onset of infection, remained at a high level for at least 2 months, and declined slightly by 6 months. In comparison, the IgM antibodies decreased more rapidly, whereas the IgG antibodies persisted longer at a steady level. By 6 months the mean levels of the different antibodies had declined from their maximal mean levels as follows: IgM, 52%; IgA, 42%; IgE, 35%; IgD, 29%; and IgG, 8%. Thus IgD and IgE antibodies, in spite of their known short half lives, persisted longer than IgM and IgA antibodies, which limits their diagnostic value. The IgA antibody responses were found too variable to substitute for IgM antibody determination in diagnosis of a recent rubella virus infection from a single serum specimen. Comparison of maternal and cord blood sera indicated that, in addition to IgG antibodies, rubellaspecific IgD antibodies were found to cross the placenta.