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Neutralizing antibody and interferon‐α in cerebrospinal fluids and sera of acute aseptic meningitis
Author(s) -
Ichimura Hiroshi,
Shimase Kohichi,
Tamura Ikuo,
Kaneto Eiji,
Kurimura Osamu,
Aramitsu Yoshimi,
Kurimura Takashi
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890150304
Subject(s) - aseptic meningitis , meningitis , medicine , virology , virus , cerebrospinal fluid , titer , enterovirus , antibody , immunology , echovirus , interferon , enterovirus 71 , viral meningitis , bacterial meningitis , psychiatry
Cerebrospinal fluids (CSFs) and sera from 20 patients with echovirus 30 (E 30) meningitis, 4 patients with enterovirus 71 (EV 71) meningitis, and 5 patients with acute aseptic meningitis (AM) of unknown etiology were investigated at the acute and the convalescent phases of the disease to elucidate the roles of neutralizing antibody (NT) and interferon‐α (IFN‐α) in the central nervous system (CNS) in cases of AM in humans. Viruses were isolated from the CSFs at the acute phase of AM, but not at the convalescent phase. There was a fourfold or greater rise in NT titer between paired sera to E 30 or EV 71 but only a slight rise between paired CSFs. IFN‐α was detected in the CSFs ranging from <10 to 25.5 IU/ml but not in the sera, and the IFN‐α level in the CSF was significantly higher in the acute phase than in the convalescent phase. These results suggest that in cases of acute enteroviral infections in the CNS, NT plays only a small role in the recovery from AM, and IFN‐α plays a direct or indirect role in curbing the local spread of the virus and eliminating the virus from the CNS at the acute phase of AM.