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Neurotropism of a high‐passage XJ strain of junín virus
Author(s) -
Oubiña José R.,
Carballal Guadalupe
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890150208
Subject(s) - virology , strain (injury) , virus , tropism , guinea pig , immunofluorescence , biology , junin virus , tissue tropism , serial passage , antigen , antibody , immunology , anatomy , lymphocytic choriomeningitis , endocrinology , cd8
Guinea pig infection with a highly passaged XJ prototype strain of Junín virus by the intramuscular route (IM) was carried out in order to study viral tropism modification in this host. The neurotropism of this strain was demonstrated by viral isolation, meningitis, and by the presence of Junin antigens as shown by immunofluorescence. These events, not previously observed with the same lower‐passaged strain, revealed the appearance of neurotropism after multiple passages in guinea pigs.