Premium
Horizontal transmission of hepatitis B virus among children and adults in five rural villages in Zambia
Author(s) -
Tabor E.,
Bayley A. C.,
Cairns J.,
Pelleu L.,
Gerety R. J.
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890150203
Subject(s) - transmission (telecommunications) , serology , medicine , hepatitis b virus , horizontal transmission , virology , vaccination , hepatitis b , virus , pediatrics , viral disease , immunology , antibody , electrical engineering , engineering
To determine whether horizontal transmission of the hepatitis B virus contributes to the high prevalence of infection with this virus in an endemic region, residents of five villages in Zambia were tested for hepatitis B serologic markers. The prevalence of hepatitis B was determined by testing samples from 620 residents. By examining paired serum samples from 79 children and 80 adults, it was determined that new infections occurred during the five years of this study in at least 14 children (18%) (aged 4–17 years) and ten adults (12%) (aged 23–65 years). These 24 new infections were distributed among 20 households and were not associated with active HBV infections in the mother or, in most cases, other family members. Intervention to prevent hepatitis B in regions such as rural Zambia will require vaccination of susceptible children and adults as well as newborn infants.