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Immunogenicity of a five‐microgram dose of hepatitis B vaccine
Author(s) -
Papaevangelou George,
RoumeliotouKarayannis Anastasia,
Vissoulis Charalambos,
Richardson StevenClive,
Krugman Saul
Publication year - 1985
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890150109
Subject(s) - microgram , immunogenicity , seroconversion , titer , medicine , booster dose , vaccination , population , hepatitis b vaccine , virology , immunology , hepatitis b virus , antibody , virus , biology , hbsag , in vitro , biochemistry , environmental health
The immunogenicity of a 5‐μg dose of vaccine (H‐B‐Vax, MSD) was evaluated in 50 young adults (17–19 years). Results were compared to our previous studies using similarly prepared vaccines using 20 μg and 10 μg per dose with the same trial protocol in a comparable population. Seroconversion rates for the 5‐μg doses of vaccine were 80% after the first dose and 98% after the second dose. The remaining participants did not develop anti‐HBs in the course of the trial. These results are not significantly different from those observed in the 10‐μg and 20‐μg studies. The increase of anti‐HBs titers was slower for the 5‐μg group. High geometric mean titers were observed after booster vaccination, but lower for the 5μg (3,591 mIU/ml) than for 10 μg (9,277 mIU/ml) and 20 μg (12,975mIU/ml) doses. It is concluded that 5‐μg dose of the vaccine is effectively immunogenic for young adults.