Immunogenic effect of hepatitis B vaccine in children: Comparison of two‐and three‐dose protocols | Zendy

Yvonnet Bernard | Zendy; Coursaget Pierre | Zendy; Petat Eric | Zendy; Tortey Eric | Zendy; Diouf Cheikh | Zendy; Barin Francis | Zendy; Denis Francois | Zendy; DiopMar Ibrahima | Zendy; Chiron JeanPaul | Zendy

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Immunogenic effect of hepatitis B vaccine in children: Comparison of two‐and three‐dose protocols

Author(s) -

Yvonnet Bernard,

Coursaget Pierre,

Petat Eric,

Tortey Eric,

Diouf Cheikh,

Barin Francis,

Denis Francois,

DiopMar Ibrahima,

Chiron JeanPaul

Publication year - 1984

Publication title -

journal of medical virology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.782

H-Index - 121

eISSN - 1096-9071

pISSN - 0146-6615

DOI - 10.1002/jmv.1890140207

Subject(s) - virology , hepatitis b vaccine , medicine , hepatitis b virus , immunology , biology , virus , hbsag

The immunogenic effect of hepatitis B vaccine was evaluated in 183 seronegative infants from Senegal. Seventy‐two seronegative infants received two 5‐μg doses of vaccine at a two‐month interval and 111 seronegative infants received three 5‐μg doses at one—month intervals. All the children had a booster dose one year after the first injection of vaccine. No difference between the two groups was observed in the seroconversion rate (93.1% and 94.6%, respectively); in the proportion of high anti—HBs titer; or in the anti—HBs geometric mean titer (82 and 92 mIU/ml, respectively). These results demonstrate that two doses of 5μg of hepatitis B vaccine are sufficient in infants to obtain a high immunogenic effect.

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