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Immunogenic effect of hepatitis B vaccine in children: Comparison of two‐and three‐dose protocols
Author(s) -
Yvonnet Bernard,
Coursaget Pierre,
Petat Eric,
Tortey Eric,
Diouf Cheikh,
Barin Francis,
Denis Francois,
DiopMar Ibrahima,
Chiron JeanPaul
Publication year - 1984
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890140207
Subject(s) - virology , hepatitis b vaccine , medicine , hepatitis b virus , immunology , biology , virus , hbsag
The immunogenic effect of hepatitis B vaccine was evaluated in 183 seronegative infants from Senegal. Seventy‐two seronegative infants received two 5‐μg doses of vaccine at a two‐month interval and 111 seronegative infants received three 5‐μg doses at one—month intervals. All the children had a booster dose one year after the first injection of vaccine. No difference between the two groups was observed in the seroconversion rate (93.1% and 94.6%, respectively); in the proportion of high anti—HBs titer; or in the anti—HBs geometric mean titer (82 and 92 mIU/ml, respectively). These results demonstrate that two doses of 5μg of hepatitis B vaccine are sufficient in infants to obtain a high immunogenic effect.