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Evaluation of the effectiveness of 2H‐1, 3‐Oxazine‐2,6(3H)‐dione (Oxauracil) in the treatment of herpes simplex virus (HSV)‐Induced acute encephalitis in mice
Author(s) -
Seal Lawton A.,
Jamison Richard M.
Publication year - 1984
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890130408
Subject(s) - herpes simplex virus , virology , encephalitis , hsl and hsv , virus , medicine , biology
Treatment of suckling mice with the pyrimidine analogue 2H‐1,3‐oxazine‐2,6(3H)‐dione (oxauracil) proved successful in reducing mortality associated with HSV‐2‐induced encephalitis. Oxauracil did not decrease mortality associated with HSV‐1 infection; however, there was an increased survival time and a decrease in the amount of infectious virus recovered from the brains of HSV‐1‐infected animals.