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Community‐acquired non‐A, non‐B hepatitis: Clinical characteristics and chronicity
Author(s) -
Sampliner Richard E.,
Woronow Daniel I.,
Alter Miriam J.,
Smallwood Linda A.,
Tabor Edward,
Deinhardt Friedrich,
Roggendorf Michael,
Gerety Robert J.
Publication year - 1984
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890130203
Subject(s) - medicine , hepatitis , hepatitis b , prothrombin time , viral hepatitis , bilirubin , gastroenterology , hepatic encephalopathy , hepatitis a , hepatitis c , immunology , cirrhosis
The characteristics of 86 patients with acute non‐A, non‐B hepatitis were compared to 23 patients with acute hepatitis A and 76 with acute hepatitis B by medical record reviews of patients seen at 5 hospitals in Baltimore, Maryland, as part of case‐control study of viral hepatitis. Results of serum aminotransferase levels, bilirubin, albumin, and prothrombin times alone could not distinguish the type of viral hepatitis because of extensive overlap. The alanine aminotransferase range for non‐A, non‐B hepatitis was 56 to 1819 IU/liters, for hepatitis A 250 to 1995 IU/liters, and for hepatitis B 203 to 2120 IU/liters. The ranges of aspartate aminotransferase and bilirubin for the types of hepatitis also overlapped. Fewer patients with non‐A, non‐B hepatitis or hepatitis A had a prolonged prothrombin time compared to patients with hepatitis B. Hepatic encephalopathy was seen only in two patients with hepatitis B. Forty‐two percent of non‐A, non‐B hepatitis patients followed for 6 months or longer continued to have elevated alanine aminotransferase levels. Chronic alanine aminotransferase elevation was independent of the source of infection: transfusion, parenteral drug use, or all other sources. Prolonged follow‐up is necessary to evaluate chronicity in patients with non‐A, non‐B hepatitis.