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Modulation of production of hepatitis B surface antigen by a human hepatoma cell line
Author(s) -
Clementi Massimo,
Bagnarelli Patrizia,
Pauri Paola,
Calegari Letizia
Publication year - 1984
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890130202
Subject(s) - hbsag , virology , cell culture , antigen , microbiology and biotechnology , hepatitis b virus , cell , biology , chemistry , virus , immunology , biochemistry , genetics
Three drugs were assayed for their capacity to inhibit hepatitis B surface antigen (HBsAg) production by the PLC/PRF/S human hepatoma cell line. The effect on cell growth and HBsAg production of Cordycepin, 6‐azauridine, and Hygromicin B is reported. Hygromicin B, a translation inhibitor unable to penetrate normal cells, greatly reduced HBsAg production by growing and confluent cells.