Premium
Cell‐mediated immunity in respiratory syncytial virus disease
Author(s) -
Scott R.,
Pullan C. R.,
Scott M.,
McQuillin J.
Publication year - 1984
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/jmv.1890130112
Subject(s) - virus , antibody , immunology , virology , respiratory system , cellular immunity , immunity , cord blood , titer , medicine , pneumovirinae , immunofluorescence , biology , paramyxoviridae , cell , viral disease , immune system , genetics
Systemic cell‐mediated responses to respiratory syncytial (RS) virus were detected, using a whole blood transformation assay, in 10 of 28 infants and children with RS virus infections during the period 1–14 days postadmission. Cell‐mediated responses were unrelated to the age of the patient or the severity of illness. No correlation was found between cellular responses and fourfold or greater rises in antibody titre to RS virus, as determined by a membrane immunofluorescence technique. Patients under 6 months of age had significantly lower levels of IgA and IgG antibody to RS virus compared to older patients, although cell‐mediated responses were similar in both groups. The presence of cell‐mediated reactivity to RS virus was also demonstrated in 5 of 95 samples of cord blood examined, and cellular responses failed to correlate with the levels of IgG antibody to RS virus.